ZENAPAX

Drug Name: ZENAPAX

ZENAPAX DESCRIPTION:
DACLIZUMAB - INJECTION (dack-LIZ-you-mab)

COMMON ZENAPAX BRAND NAME(S):
Zenapax

ZENAPAX SIDE EFFECTS:
Nausea, vomiting, constipation or diarrhea may occur. If these effects persist or worsen, notify your doctor. Report promptly: stomach pain, headache, dizziness, chest pain, arm or leg swelling, trouble breathing, coughing, sore throat, fever, poor wound healing, bleeding, muscle pain, increased thirst or hunger, cloudiness or unusual change in amount of urine. Unlikely but report promptly: bloody urine or stools, weakness, leg cramps, increased sweating, mood/mental changes, arthritis pain, pain at the site of injection. In the unlikely event you have an allergic reaction to this drug, seek medical attention immediately. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.

HOW TO USE ZENAPAX:
ZENAPAX: ZENAPAX is given by injection into a vein (IV) after proper dilution in a saline solution. The dose is given over a 15 minute period, every 14 days for a total of 5 doses, beginning no more than 24 hours before transplantation. Review all the preparation and administration instructions in the product package and ask your doctor or pharmacist if any information is unclear. Do not use if solution is cloudy or colored. Do not shake the vial. ZENAPAX should be given by a health care professional.

ZENAPAX USES:
ZENAPAX is used to prevent organ rejection in patients receiving kidney transplants. ZENAPAX is used in combination with other drugs (e.g., cyclosporine and steroids).

OTHER USES OF ZENAPAX:
ZENAPAX may also be used for other types of organ transplants.

ZENAPAX PRECAUTIONS:
Before using ZENAPAX, tell your doctor your medical history, including: allergies (especially drug allergies), heart or lung disease, diabetes, high blood pressure, cancer, serious infection. Limit alcohol intake as it may enhance certain side effects of ZENAPAX. Since ZENAPAX may cause dizziness, use extreme caution if operating machinery or performing hazardous tasks (e.g., driving). It is recommended that women of childbearing age should use effective birth control before, during, and for 4 months following the use of this product. ZENAPAX should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known whether ZENAPAX is excreted into breast milk. Because of the potential risk to the infant, breast-feeding while using ZENAPAX is not recommended. Consult your doctor before breast-feeding. Caution is advised when ZENAPAX is used in the elderly.

ZENAPAX DRUG INTERACTIONS:
Tell your doctor of all nonprescription and prescription medication you may use, especially of: steroids (e.g., prednisone), other immunosuppressive drugs (e.g., cyclosporine, mycophenolate, azathioprine). Do not start or stop any medicine without doctor or pharmacist approval.

ZENAPAX OVERDOSE:
If overdose is suspected, contact your local poison control center or emergency room immediately.

ZENAPAX NOTES:
Do not share ZENAPAX with others. Monitoring, including laboratory tests, is performed during use of ZENAPAX.

MISSED ZENAPAX DOSE:
If you miss a dose, consult your doctor or pharmacist to establish a new dosing schedule promptly.

ZENAPAX STORAGE:
Vials should be refrigerated between 36 and 46 degrees F (2-8 degrees C) away from light. Do not shake or freeze. Diluted medication is stable for 24 hours at 39 degrees F (4 degrees C), or for 4 hours at room temperature. Discard any unused portion of the vial. Your condition can cause complications in a medical emergency. For information on enrollment call Medic Alert TM at 1-800-854-1166. In Canada call 1-800-668-1507.