Uprima - 2MG

Drug Name: UPRIMA

UPRIMA - ORAL (Abbott Laboratories Ltd)

COMMON UPRIMA BRAND NAME(S):
Uprima

UPRIMA USES:
Uprima is a prescription medication used for the treatment of male erectile dysfunction or ED. Erectile dysfunction is a condition in which a man cannot achieve an erection sufficient enough for intercourse. Uprima helps men achieve erections by stimulating the region of the brain called the hypothalamus. As a result, the body increases the production of dopamine, an important chemical in the body that helps trigger erection.

HOW TO USE UPRIMA:
The normal recommended Uprima dose for is one 2 mg Uprima tablet 20 minutes before engaging in sexual activity. Before you take Uprima, drink a full glass of water. This will help the Uprima tablet dissolve properly. After drinking the water, place the Uprima tablet under your tongue and let it dissolve slowly.

UPRIMA SIDE EFFECTS:
Uprima, like all medications, may cause side effects. These side effects are generally mild in nature. In most cases they do not require you to quit treatment as a result. Common side effects of Uprima are nausea, headache, dizziness, yawning, sleepiness, infection, sore throat, pain, increased cough, rhinitis, flushing, taste disorder and/or sweating. In very rare incidences after using Uprima fainting might occur. If you feel faint, lie down and raise your legs. This should help alleviate any symptoms of faintness. If you experience chest pains during intercourse, stop immediately and contact your doctor. If prolonged side effects from Uprima occur or if you experience any one of the previous symptoms, stop Uprima treatment and consult with your doctor immediately.

UPRIMA PRECAUTIONS:
Uprima is a prescription medication intended for healthy men only. Uprima is not approved for women or children. Do not take Uprima if:
You have ever had an allergic reaction to apomorphine or any other ingredients found in Uprima. You suffer from severe unstable angina, recent myocardial infarction, severe heart failure, hypertension, or any other heart problems. Your partner is pregnant or breast-feeding. If you fall under any one of the following conditions, use extra precautions while taking Uprima and consult with your doctor before taking Uprima: You have a deformity or disease of the penis. You experience severe dizziness or feel faint after taking Uprima. You are taking medications with nitrates. You have liver or kidney problems. You have abnormally high blood pressure. You are taking other treatments for erectile dysfunction other than Uprima.

UPRIMA DRUG INTERACTIONS:
The combination of Uprima with both nitrates and antihypertensives (angiotensin-converting enzyme (ACE) inhibitors beta-blockers, calcium channel blockers, and alpha-blockers) has been studied. The only significant findings were in the group of patients who were taking nitrates. Since apomorphine is primarily metabolised by sulphation and glucuronidation, compounds that Inhibit or induce cytochrome P450 isotorms are not expected to affect the pharmacokinetics of apomorphine. Uprima interaction studies in volunteers where alcohol was given with Uprima indicated that concurrent alcohol intake may cause an increase in the incidence and extent of hypotension. It IS therefore recommended that caution be observed when administering Uprima to patients taking nitrates. No studies have been performed with Uprima in combination with other antiemetics hence other combinations are not recommended. Uprima interaction studies and/or clinical experience with ondansetron hydrochloride prochlorperazine maleate and domperidone indicate that these agents may be given safely with Uprima. A proportion (4/40) of these patients experienced vasovagal symptoms and significant standing blood pressure decreases when Uprima was administered at higher than the recommended dose (5mg).

UPRIMA OVERDOSE:
The use of domperidone maleate a peripherally acting dopamine antagonist used to counter emetic effects may be considered. Uprima In high doses may induce vomiting. It is advised that vital signs such as blood pressure and heart rate are monitored. Treatment should be supportive and symptomatic. Measures to avoid possible orthostatic hypotension should be taken. If the Uprima tablets are swallowed the bioavailability of apomorphine will be reduced by first pass metabolism. There is no specific antidote available for Uprima.

UPRIMA NOTES:
A minimum time period of 8 hours should be allowed to elapse prior to administering a subsequent Uprima dose. One Uprima tablet should be administered approximately 20 minutes prior to sexual activity. It is recommended that the patient be started at the Uprima 2mg dose. The dose may be increased on subsequent administrations to 3mg of Uprima if necessary to reach the desired clinical effect.

MISSED UPRIMA DOSE:
Not applicable for Uprima medication.

UPRIMA STORAGE:
Store Uprima at room temperature between 59 and 86 degrees F (15 to 30 degrees C) away from heat and light. Do not store Uprima in a moist bathroom. Keep Uprima and all medications out of the reach of children.